HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Protective effects of different marigold (Calendula officinalis L.) and rosemary cream preparations against sodium-lauryl-sulfate-induced irritant contact dermatitis.

Abstract
In the present study, we evaluated the protective action of cream preparations containing seven different types of marigold and rosemary extracts in vivo in healthy volunteers with experimentally induced irritant contact dermatitis (ICD). Marigold and rosemary extracts in base cream DAC (Deutscher Arzneimittel-Codex = German Pharmaceutical Codex) were tested in a 4-day repetitive irritation test using sodium lauryl sulfate. The effect was evaluated visually and quantified by noninvasive bioengineering methods, namely chromametry and tewametry. When the test products were applied parallel to the induction period of ICD, a statistically significant protective effect of all cream preparations was observed by all methods. This effect, although not statistically significant, was superior to control by undyed marigold und faradiol ester-enriched extracts in chromametry and by dyed and undyed rosemary extracts in tewametry. The sequential treatment (postirritation) once a day for 5 days was without any effect. Thus, a protective effect of some marigold and rosemary extracts against ICD could be shown in the elicitation phase.
AuthorsS M Fuchs, S Schliemann-Willers, T W Fischer, P Elsner
JournalSkin pharmacology and physiology (Skin Pharmacol Physiol) 2005 Jul-Aug Vol. 18 Issue 4 Pg. 195-200 ISSN: 1660-5527 [Print] Switzerland
PMID15908760 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright (c) 2005 S. Karger AG, Basel.
Chemical References
  • Anti-Inflammatory Agents
  • Plant Extracts
  • Sodium Dodecyl Sulfate
  • Hydrocortisone
Topics
  • Administration, Cutaneous
  • Adolescent
  • Adult
  • Anti-Inflammatory Agents (therapeutic use)
  • Calendula
  • Dermatitis, Irritant (drug therapy, etiology)
  • Female
  • Humans
  • Hydrocortisone (therapeutic use)
  • Male
  • Plant Extracts (therapeutic use)
  • Rosmarinus
  • Single-Blind Method
  • Sodium Dodecyl Sulfate (toxicity)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: