Abstract | BACKGROUND: Acute inflammation has a negative effect on the muscular system in elderly patients, compromising the outcome of the underlying disease. OBJECTIVE: The aim of this study was to evaluate the effect of cyclooxygenase-2 (COX-2) inhibition on muscle performance and mobility in hospitalized elderly patients with acute inflammation of infectious origin. METHODS: RESULTS: Forty-three consecutively hospitalized elderly patients (31 women, 12 men; mean [SD] age, 84 [6] years) were enrolled. Fourteen patients received celecoxib, 14 received acetaminophen, and 15 received no supplementary medication. The change in fatigue resistance was significantly different between groups (P = 0.021, Kruskal-Wallis chi-square test), with significantly greater improvement in patients receiving celecoxib compared with the acetaminophen and control groups (63% increase from baseline; P < 0.05). There were no significant between-group differences in changes in grip strength, mobility, IL-1beta, IL-6, TNF-alpha, or TGF-beta. The changes in levels of IL-10 differed significantly between groups (P = 0.020, Kruskal-Wallis chi-square test), with greater improvement in the celecoxib group compared with the acetaminophen group (P = 0.032). CONCLUSION: The results of this study suggest that COX-2-selective inhibition has a beneficial effect on muscle fatigue resistance in hospitalized elderly patients with acute inflammation of infectious origin. However, until further trials are conducted, the use of COX-2-selective inhibitors for this indication is not recommended.
|
Authors | Tony Mets, Ivan Bautmans, Rose Njemini, Margareta Lambert, Christian Demanet |
Journal | The American journal of geriatric pharmacotherapy
(Am J Geriatr Pharmacother)
Vol. 2
Issue 4
Pg. 230-8
(Dec 2004)
ISSN: 1543-5946 [Print] United States |
PMID | 15903281
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Cyclooxygenase Inhibitors
- Cytokines
- Pyrazoles
- Sulfonamides
- C-Reactive Protein
- Celecoxib
|
Topics |
- Acute Disease
- Aged
- Aged, 80 and over
- C-Reactive Protein
(metabolism)
- Celecoxib
- Cyclooxygenase Inhibitors
(therapeutic use)
- Cytokines
(metabolism)
- Female
- Hand Strength
- Humans
- Infections
(complications, physiopathology)
- Inflammation
(drug therapy, etiology, metabolism)
- Male
- Movement
(drug effects)
- Muscle Fatigue
(drug effects)
- Pyrazoles
(therapeutic use)
- Single-Blind Method
- Sulfonamides
(therapeutic use)
|