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Duration of human chorionic gonadotropin surveillance for partial hydatidiform moles.

AbstractOBJECTIVE:
Partial hydatidiform moles infrequently progress to gestational trophoblastic neoplasia. The purpose of this study was to determine the optimal duration of human chorionic gonadotropin surveillance.
STUDY DESIGN:
We retrospectively reviewed the clinical follow-up of all women who were diagnosed with partial hydatidiform mole at our institution from 1983 to 2003.
RESULTS:
One hundred sixty-three patients were identified with a median age of 23 years (range, 14-42 years). Seventy-four patients (45%) attained undetectable levels of human chorionic gonadotropin; none of the patients had gestational trophoblastic neoplasia. Forty patients completed the 6 months of recommended follow-up; 6 patients conceived during surveillance, and 28 patients did not return for any further office visits 1 to 5 months after achieving remission. Eighty-three patients (51%) were lost to follow-up before normalization of human chorionic gonadotropin. Six women (4%) had stage I gestational trophoblastic neoplasia during surveillance.
CONCLUSION:
Our results support the suggestion that a single undetectable human chorionic gonadotropin level after evacuation is sufficient follow-up to ensure remission in patients with partial hydatidiform moles.
AuthorsIsaac Lavie, Gautam G Rao, Diego H Castrillon, David S Miller, John O Schorge
JournalAmerican journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 192 Issue 5 Pg. 1362-4 (May 2005) ISSN: 0002-9378 [Print] United States
PMID15902109 (Publication Type: Journal Article)
Chemical References
  • Chorionic Gonadotropin
Topics
  • Adolescent
  • Adult
  • Chorionic Gonadotropin (blood)
  • Female
  • Gestational Trophoblastic Disease (blood, diagnosis, epidemiology, pathology)
  • Humans
  • Hydatidiform Mole (blood, surgery)
  • Incidence
  • Neoplasm Staging
  • Population Surveillance
  • Postoperative Period
  • Pregnancy
  • Retrospective Studies
  • Time Factors

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