Abstract | CONTEXT: EVIDENCE ACQUISITION: EVIDENCE SYNTHESIS: The most important aspect of treatment is targeted at modification of the underlying disease. However, approaches to symptomatic pain control are essential and include multiple drug classes. Tricyclic antidepressants, including imipramine, nortriptyline, and amitriptyline, have been the mainstays of treatment, but anticholinergic effects, such as dry mouth, blurring of vision, constipation, orthostatic hypotension, and cardiac arrhythmias, as well as other adverse effects, often limit their use. Other treatments include capsaicin, clonidine, acupuncture, and electrical stimulation, suggesting that there is no single effective treatment. First-generation antiepileptic drugs have been shown to be effective in neuropathic pain. The evidence supporting the use of a new generation of antiepileptic drugs in painful diabetic neuropathy is reviewed.
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Authors | Aaron Vinik |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 90
Issue 8
Pg. 4936-45
(Aug 2005)
ISSN: 0021-972X [Print] United States |
PMID | 15899953
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
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Topics |
- Anticonvulsants
(therapeutic use)
- Chronic Disease
- Clinical Trials as Topic
- Diabetic Neuropathies
(drug therapy)
- Humans
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