Abstract | STUDY OBJECTIVE: DESIGN: Multicenter, double-blind, randomized, controlled trial. SETTING: Two university-affiliated medical centers in Italy. PATIENTS: INTERVENTION: MEASUREMENTS AND MAIN RESULTS: Body mass index (BMI), glycemic control, and coagulation and fibrinolysis parameters were evaluated at 3, 6, 9, and 12 months of treatment. Compared with baseline values, significant decreases in BMI, fasting plasma glucose, postprandial plasma glucose, and hemoglobin A1c were observed at 12 months in both the glimepiride and rosiglitazone groups (p<0.05 and p<0.01, respectively). Decreases in fasting plasma insulin and postprandial plasma insulin were observed at 12 months (p<0.05 and p<0.01, respectively) compared with baseline values in the rosiglitazone group. Furthermore, improvement in the Homeostasis Model Assessment index was observed only at 9 and 12 months (p<0.05 and p<0.01, respectively) compared with baseline in the rosiglitazone group. Significant improvement in plasminogen activator inhibitor (PAI)-1 was present in the rosiglitazone group after 9 months (p<0.05), and significant PAI-1 improvement was observed in the glimepiride and rosiglitazone groups after 12 months (p<0.05 and p<0.01, respectively). CONCLUSIONS:
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Authors | Giuseppe Derosa, Antonio V Gaddi, Mario N Piccinni, Leonardina Ciccarelli, Sibilla Salvadeo, Emmanouil Peros, Morena Ghelfi, Ilaria Ferrari, Arrigo F G Cicero |
Journal | Pharmacotherapy
(Pharmacotherapy)
Vol. 25
Issue 5
Pg. 637-45
(May 2005)
ISSN: 0277-0008 [Print] United States |
PMID | 15899724
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Blood Glucose
- Fibrinolytic Agents
- Glycated Hemoglobin A
- Hypoglycemic Agents
- Plasminogen Activator Inhibitor 1
- Sulfonylurea Compounds
- Thiazolidinediones
- Rosiglitazone
- glimepiride
- Fibrinogen
- Metformin
- Tissue Plasminogen Activator
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Topics |
- Blood Glucose
(analysis)
- Diabetes Mellitus, Type 2
(blood, drug therapy)
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Fibrinogen
(metabolism)
- Fibrinolytic Agents
(administration & dosage, therapeutic use)
- Glycated Hemoglobin
(analysis)
- Humans
- Hypoglycemic Agents
(administration & dosage, therapeutic use)
- Male
- Metabolic Syndrome
(blood, drug therapy)
- Metformin
(administration & dosage, therapeutic use)
- Middle Aged
- Plasminogen Activator Inhibitor 1
(blood)
- Rosiglitazone
- Sulfonylurea Compounds
(administration & dosage, therapeutic use)
- Thiazolidinediones
(administration & dosage, therapeutic use)
- Tissue Plasminogen Activator
(blood)
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