[Cyclooxygenase 2 inhibitors and adenomatous polyposis coli].

Abstract

Prolonged use of aspirin and\or non-steroidal anti-inflammatory drugs induces a partial regression of either sporadic adenomas or adenomas in adenomatous polyposis coli (APC), but also their emergence and colonic cancer development in sporadic adenomas. Specific inhibitors of cyclooxygenase of type 2 (Cox2) induce less upper and lower digestive tract adverse events that non-specific anti-inflammatory drugs. This better tolerance might allow a long-lasting use in patients with APC. At time, we don't know if such treatments are able to prevent the development of cancer in the rectum or duodenum of these patients. In this paper we will discuss the scientific proofs and potential interest of Cox2 inhibitors in the treatment of PAF.

• Authors: Christian Florent, Nathalie Meary
• Journal: Bulletin du cancer (Bull Cancer) Vol. 91 Suppl 2 Pg. S85-8 (May 2004) ISSN: 1769-6917 [Electronic] France
• Vernacular Title: Inhibiteurs spécifiques de la cyclo-oxygénase 2 et polypose adénomateuse familiale.
• PMID: 15899631 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Antineoplastic Agents
• Cyclooxygenase Inhibitors
• Aspirin

Topics

• Adenomatous Polyposis Coli (prevention & control)
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects, therapeutic use)
• Antineoplastic Agents (adverse effects, therapeutic use)
• Aspirin (adverse effects, therapeutic use)
• Cyclooxygenase Inhibitors (adverse effects, therapeutic use)
• Humans