A clinical-radiological evaluation of benzimidazoles in the management of Echinococcus granulosus cysts.

Abstract

Nine patients with complicated hydatid disease managed with surgery and mebendazole/albendazole are presented. Five patients received albendazole (1 treatment course) and 5 patients received mebendazole (3 had 2 treatment courses, 1 had a switch-over from mebendazole to albendazole). The mean durations of treatment and follow-up were respectively 7 +/- 2.5 months and 7 +/- 2.5 months (albendazole); 13 +/- 10 months and 29 +/- 31 months (mebendazole). A superior clinical and radiological response was seen in 1 patient with disseminated intra-abdominal disease on switching therapy from mebendazole to albendazole. Radiological improvement occurred in 3/5 courses of albendazole and in 2/8 courses of mebendazole. Clinical improvement occurred in 3/5 courses of albendazole and 0/8 courses of mebendazole. Radiological deterioration was demonstrated in 0/5 courses of albendazole and 2/8 courses of mebendazole. Although the impression was that albendazole was superior, good responses were also seen with mebendazole. The heterogeneity of the patients, their disease, short follow-up time, lack of more sensitive noninvasive assay techniques urges caution before firm conclusions can be drawn.

• Authors: M Ellis, W von Sinner, A Al-Hokail, J Sieck
• Journal: Scandinavian journal of infectious diseases (Scand J Infect Dis) Vol. 24 Issue 1 Pg. 1-13 ( 1992) ISSN: 0036-5548 [Print] England
• PMID: 1589713 (Publication Type: Case Reports, Journal Article)

Chemical References

• Mebendazole
• Albendazole

Topics

• Abdomen (surgery)
• Adult
• Aged
• Albendazole (therapeutic use)
• Child
• Debridement
• Drug Therapy, Combination
• Echinococcosis (diagnostic imaging, drug therapy, surgery, therapy)
• Echinococcosis, Hepatic (diagnostic imaging, drug therapy, surgery)
• Female
• Humans
• Male
• Mebendazole (therapeutic use)
• Middle Aged
• Time Factors
• Tomography, X-Ray Computed