Falsely low LDL-cholesterol concentrations and artifactual undetectable HDL-cholesterol measured by direct methods in a patient with monoclonal paraprotein.

Multiple myeloma is a malignant immunoproliferative disorder with lipoprotein abnormalities. We report a case of falsely low concentrations of LDL-cholesterol (LDL-C) and artifactural undetectable HDL-cholesterol (HDL-C) as measured with direct methods in a patient of multiple myeloma with IgGkappa monoclonal gammapathy and significant hyperlipidemia.
The patient had HDL-C and LDL-C concentrations in the 0.63-0.71 mmol/l and 2.22-2.36 mmol/l ranges, respectively, as measured by a traditional semi-quantitative electrophoresis method. The observation of falsely low concentrations of LDL-C and artifactural undetectable HDL-C might result in the mismanagement of patients of multiple myeloma with monoclonal gammapathy, because the LDL-C and HDL-C concentrations are positive and negative risk factors of cardiovascular diseases.
Care must be taken when using the homogenous method for direct measurement of LDL-cholesterol and HDL-cholesterol in patients of multiple myeloma with monoclonal paraprotein.
AuthorsLi-Yu Tsai, Shih-Men Tsai, Su-Chen Lee, Shu-Fen Liu
JournalClinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 358 Issue 1-2 Pg. 192-5 (Aug 2005) ISSN: 0009-8981 [Print] Netherlands
PMID15896728 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antibodies, Monoclonal
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Immunoglobulin G
  • Paraproteins
  • Aged
  • Antibodies, Monoclonal (blood)
  • Artifacts
  • Cholesterol, HDL (blood)
  • Cholesterol, LDL (blood)
  • Electrophoresis (methods)
  • Female
  • Humans
  • Hyperlipidemias (blood, complications, diagnosis)
  • Immunoglobulin G (analysis)
  • Multiple Myeloma (blood, complications, diagnosis)
  • Paraproteinemias (blood, complications, diagnosis)
  • Paraproteins (analysis)

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