New antibiotic Sch 725424 and its dehydration product Sch 725428 from Kitasatospora sp.

Abstract

A new microbial metabolite Sch 725424 (1) was isolated from the culture of Kitasatospora sp. The structure elucidation of 1 was accomplished based on NMR spectroscopic analyses as well as extensive structure elucidation of its dehydration product Sch 725428 (2). Compound 1 showed inhibitory activity against Staphylococcus aureus with MIC values 1-2 microg/ml, and also displayed weak antifungal activity against Saccharomyces cerevisiae (PM503) with an MIC 32 microg/ml.

• Authors: Shu-Wei Yang, Tze-Ming Chan, Joseph Terracciano, Reena Patel, David Loebenberg, Guodong Chen, Mahesh Patel, Vincent Gullo, Birendra Pramanik, Min Chu
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 58 Issue 3 Pg. 192-5 (Mar 2005) ISSN: 0021-8820 [Print] England
• PMID: 15895527 (Publication Type: Journal Article)

Chemical References

• Amides
• Anti-Bacterial Agents
• Antifungal Agents
• Furans
• Polyenes
• Sch 725424
• Sch 725428

Topics

• Amides (chemistry, metabolism, pharmacology)
• Anti-Bacterial Agents (biosynthesis, chemistry, pharmacology)
• Antifungal Agents (chemistry, metabolism, pharmacology)
• Fermentation
• Furans (chemistry, metabolism, pharmacology)
• Magnetic Resonance Spectroscopy
• Microbial Sensitivity Tests
• Molecular Structure
• Polyenes (chemistry, metabolism, pharmacology)
• Saccharomyces cerevisiae (drug effects)
• Staphylococcus aureus (drug effects)
• Streptomycetaceae (metabolism)