No evidence for association between polymorphisms in GRM3 and schizophrenia.

Abstract

BACKGROUND:

Three studies have previously reported data that were interpreted by the authors as supportive of association between schizophrenia and polymorphisms in the gene encoding the metabotropic glutamate receptor GRM3.

METHODS:

In a bid to examine this hypothesis, we examined seven SNPs spanning GRM3 in a UK case-control sample (schizophrenic cases n = 674, controls n = 716). These included all SNPs previously reported to be associated, alone or in haplotypes, with schizophrenia in European or European American samples.

RESULTS:

Our data showed no evidence for association with single markers, or 2, 3, 4 and 5 marker haplotypes, nor did any specific haplotypes show evidence for association according to previously observed patterns.

CONCLUSION:

Examination of our own data and those of other groups leads us to conclude that at present, GRM3 should not be viewed as a gene for which there is replicated evidence for association with schizophrenia.

• Authors: Nadine Norton, Hywel J Williams, Sarah Dwyer, Dobril Ivanov, Anna C Preece, Amy Gerrish, Nigel M Williams, Pamela Yerassimou, Stanley Zammit, Michael C O'Donovan, Michael J Owen
• Journal: BMC psychiatry (BMC Psychiatry) Vol. 5 Pg. 23 (May 13 2005) ISSN: 1471-244X [Electronic] England
• PMID: 15892884 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Genetic Markers
• Receptor, Metabotropic Glutamate 5
• Receptors, Metabotropic Glutamate

Topics

• Adult
• Case-Control Studies
• Female
• Gene Frequency
• Genetic Markers
• Genetic Predisposition to Disease (genetics)
• Genotype
• Haplotypes (genetics)
• Humans
• Male
• Polymorphism, Single Nucleotide (genetics)
• Receptor, Metabotropic Glutamate 5
• Receptors, Metabotropic Glutamate (genetics)
• Schizophrenia (genetics)
• White People (genetics)