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Isodomoic acid C, an unusual amnesic shellfish poisoning toxin from Pseudo-nitzschia australis.

Abstract
An unusual isomer of domoic acid (1), isodomoic acid C (2), has been found in New Zealand shellfish contaminated by amnesic shellfish poisoning (ASP) toxins and was shown to be produced by a local strain of the pennate diatom Pseudo-nitzschia australis. A bulk culture of this strain was used to isolate 2. The structure was determined from spectroscopic data and was shown to correspond to that of 2 from a Japanese red seaweed, the only other reported occurrence of this compound. The affinity of 2 for GluR6 glutamate receptors was 240-fold lower than for 1, indicating low neurotoxic potential.
AuthorsPatrick T Holland, Andrew I Selwood, Douglas O Mountfort, Alistair L Wilkins, Paul McNabb, Lesley L Rhodes, Gregory J Doucette, Christina M Mikulski, Kristen L King
JournalChemical research in toxicology (Chem Res Toxicol) Vol. 18 Issue 5 Pg. 814-6 (May 2005) ISSN: 0893-228X [Print] United States
PMID15892574 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Heptanoic Acids
  • Marine Toxins
  • Neurotoxins
  • Receptors, Glutamate
  • isodomoic acid C
Topics
  • Amnesia (chemically induced)
  • Animals
  • Diatoms (chemistry)
  • Eutrophication (physiology)
  • Foodborne Diseases
  • Heptanoic Acids (toxicity)
  • Marine Toxins (toxicity)
  • Neurotoxins (analysis, metabolism, toxicity)
  • Receptors, Glutamate (drug effects, metabolism)
  • Seaweed (chemistry)
  • Shellfish (parasitology)
  • Shellfish Poisoning

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