[Evaluation of the effects of reduced glutathione in subjects with acquired and congenital changes in heme biosynthesis].
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| Abstract |
In order to evaluate the possible therapeutical effects of reduced glutathione in subjects affected by acquired or congenital heme biosynthesis alterations, two groups of subjects have been considered: the first, of 5 subjects with abnormal lead absorption, the second of 10 patients suffering from porphyria cutanea tarda (PCT). The drug was administered i.v. at the dosage of 600-1200 mg for a variable period of 3-5 days in the first group, for 7-10 days in the patients with PCT. In the lead-exposed subjects an increase in the activity of ALA-dehydratases enzyme was observed, with a decrease in the urinary excretion of delta-aminolevulinic acid, and a decrease in the percentage of urinary coproporphyrins as well. In the patients with PCT, after the therapy, a relevant reduction of urinary excretion of porphyrins, prevalently uro- and heptaporphyrins, was noticed. The results of this preliminary study suggest that glutathione can exert an effect of "normalization" on heme biosynthesis when altered in acquired and/or congenital conditions.
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| Authors | A Ferioli, A De Vincentiis, P Buizza, G Pasolini, C Leali, G De Panfilis, L Alessio |
| Journal | Minerva medica (Minerva Med) Vol. 83 Issue 5 Pg. 269-75 (May 1992) ISSN: 0026-4806 [Print] Italy |
| Vernacular Title | Valutazione degli effetti del glutatione ridotto in soggetti con alterazioni acquisite e congenite della biosintesi dell'eme. |
| PMID | 1589131 (Publication Type: Comparative Study, English Abstract, Journal Article) |
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