[Clebopride in premedication in ambulatory interventions in general anesthesia].

Abstract

The authors examine the antiemetic effects of 1 mg clebopride administered iv after surgery, vs a placebo, by making a double blind randomized study on two groups of 40 women comparable by age and weight. The 2 groups of outpatients, admitted for short gynecological surgery, underwent diagnostic uterine curettage. They were anaesthetized with a cocktail of 2.5 mcg/kg fentanyl and 0.25 mg/kg ketamine, on spontaneous respiration. Nausea, vomiting and the other side effects were evaluated 3-6 hours after surgery. Statistically, clebopride proved more effective than placebo against nausea and vomiting (P ranging between 0.05-0.01), with no relevant side effects.

• Authors: S Migliavacca, R Speranza, M Cipolla, D Laveneziana
• Journal: Minerva anestesiologica (Minerva Anestesiol) Vol. 58 Issue 3 Pg. 117-20 (Mar 1992) ISSN: 0375-9393 [Print] Italy
• Vernacular Title: La clebopride nella premedicazione degli interventi ambulatoriali in anestesia generale.
• PMID: 1589071 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Antiemetics
• Benzamides
• clebopride

Topics

• Ambulatory Surgical Procedures
• Anesthesia, General
• Antiemetics (therapeutic use)
• Benzamides (therapeutic use)
• Female
• Humans
• Preanesthetic Medication