Floating-Harbor syndrome complicated by tethered cord: a new association and potential contribution from growth hormone therapy.

Abstract

Floating-Harbor syndrome is a rare syndrome with short stature, severely delayed bone age, typical facies and delay in expressive speech. Structural malformations are uncommon, and tethered cord or other forms of spinal dysraphism have not previously been reported. We report on a case of Floating-Harbor syndrome, complicated by tethered cord and discuss the possibility that growth hormone therapy may contribute to the development of symptoms of this malformation.

• Authors: Esko Wiltshire, Agadha Wickremesekera, Joanne Dixon
• Journal: American journal of medical genetics. Part A (Am J Med Genet A) Vol. 136 Issue 1 Pg. 81-3 (Jul 01 2005) ISSN: 1552-4825 [Print] United States
• PMID: 15889416 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright (c) 2005 Wiley-Liss, Inc.

Chemical References

• Human Growth Hormone

Topics

• Abnormalities, Multiple (drug therapy, genetics, pathology)
• Bone Diseases, Developmental (pathology)
• Child
• Face (abnormalities)
• Female
• Growth Disorders (pathology)
• Human Growth Hormone (therapeutic use)
• Humans
• Karyotyping
• Language Development Disorders (pathology)
• Spinal Dysraphism (pathology)
• Syndrome
• Treatment Outcome