Treatment of advanced malignant eccrine poroma with locoregional chemotherapy.

Abstract

Malignant eccrine poroma is a rare disease with approximately 200 cases reported in the literature. Regional cutaneous and systemic metastases are rarely observed and their management has been generally unsuccessful. We report on a case in which topical 5-fluorouracil application and intra-arterial chemotherapy with docetaxel resulted in a histologically confirmed complete response of multiple regional skin metastases for more than 2 years. Despite intravenous administration of docetaxel, slow progression of systemic disease was observed.

• Authors: E de Bree, E Volalakis, D Tsetis, Y Varthalitis, J Panagiotidis, J Romanos, D D Tsiftsis
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 152 Issue 5 Pg. 1051-5 (May 2005) ISSN: 0007-0963 [Print] England
• PMID: 15888170 (Publication Type: Case Reports, Journal Article)

Chemical References

• Taxoids
• Docetaxel
• Fluorouracil

Topics

• Acrospiroma (drug therapy, pathology)
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Disease Progression
• Docetaxel
• Fluorouracil (administration & dosage)
• Humans
• Leg
• Male
• Skin Neoplasms (drug therapy, pathology, secondary)
• Sweat Gland Neoplasms (drug therapy, pathology)
• Taxoids (administration & dosage)