Single-pill therapy in the treatment of concomitant hypertension and dyslipidemia (the amlodipine/atorvastatin gemini study).

Abstract

The Gemini Study was a 14-week, open-label, non-comparative, office-based, multicenter trial to evaluate single-pill therapy in the treatment of concomitant hypertension and dyslipidemia. In addition to recommending lifestyle modifications, eight dosage strengths of amlodipine/atorvastatin single pill (5/10, 5/20, 5/40, 5/80, 10/10, 10/20, 10/40, and 10/80 mg) were electively titrated to improve blood pressure and lipid control. A total of 1220 patients with uncontrolled hypertension at baseline received study medication. At baseline, mean blood pressure was 146.6/87.9 mm Hg and mean low-density lipoprotein cholesterol concentration was 152.9 mg/dL. At study end, 57.7% of patients had achieved both their blood pressure and low-density lipoprotein cholesterol goals (51.9% of patients with uncontrolled low-density lipoprotein cholesterol at baseline). The mean dose of study medication at end point was amlodipine component 7.1 mg and atorvastatin component 26.2 mg. Fifty-eight patients (4.8%) discontinued therapy due to adverse events. Single-pill therapy is effective in reducing both blood pressure and lipid levels and in helping patients achieve goals for both hypertension and dyslipidemia.

• Authors: Roy Blank, James LaSalle, Russell Reeves, Jaman Maroni, Lisa Tarasenko, Franklin Sun
• Journal: Journal of clinical hypertension (Greenwich, Conn.) (J Clin Hypertens (Greenwich)) Vol. 7 Issue 5 Pg. 264-73 (May 2005) ISSN: 1524-6175 [Print] United States
• PMID: 15886529 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Antihypertensive Agents
• Drug Combinations
• Heptanoic Acids
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Pyrroles
• Amlodipine
• Atorvastatin

Topics

• Adult
• Aged
• Aged, 80 and over
• Amlodipine (administration & dosage, adverse effects)
• Antihypertensive Agents (administration & dosage, adverse effects)
• Atorvastatin
• Drug Combinations
• Female
• Heptanoic Acids (administration & dosage, adverse effects)
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (administration & dosage, adverse effects)
• Hyperlipidemias (complications, drug therapy)
• Hypertension (complications, drug therapy)
• Male
• Middle Aged
• Pyrroles (administration & dosage, adverse effects)
• Treatment Outcome