Abstract | BACKGROUND: The minimal inhibitory concentrations (MICs) of erythromycin, azithromycin, clarithromycin, telithromycin, tetracycline, doxycycline, ciprofloxacin, ofloxacin, norfloxacin, levofloxacin, gemifloxacin and moxifloxacin against 78 Neisseria gonorrhoeae and 31 Ureaplasma urealyticum strains, which were isolated from patients with urethritis in Istanbul, were determined and compared. Additionally, the activities of penicillin and ceftriaxone against N. gonorrhoeae strains were explored. METHODS: MICs were determined by agar and broth dilution methods for N. gonorrhoeae and U. urealyticum, respectively. RESULTS: The susceptibility rates for penicillin and tetracycline in N. gonorrhoeae strains were 35.9 and 24.3%, respectively. All gonococcal strains were susceptible to ceftriaxone, with very low MICs (MIC90 0.008 microg/ml). Telithromycin was highly active against N. gonorrhoeae and U. urealyticum strains (MIC90 0.25 microg/ml for both). Ciprofloxacin was the most active quinolone against N. gonorrhoeae (MIC90 0.008 microg/ml) while quinolone resistance was detected in a single strain (1.3%). CONCLUSIONS:
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Authors | Derya Aydin, Omer Küçükbasmaci, Nevriye Gonullu, Zerrin Aktaş |
Journal | Chemotherapy
(Chemotherapy)
Vol. 51
Issue 2-3
Pg. 89-92
(May 2005)
ISSN: 0009-3157 [Print] Switzerland |
PMID | 15886468
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright 2005 S. Karger AG, Basel |
Chemical References |
- Anti-Bacterial Agents
- Ketolides
- telithromycin
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Topics |
- Anti-Bacterial Agents
(pharmacology)
- Drug Resistance, Bacterial
- Humans
- Ketolides
(pharmacology)
- Male
- Microbial Sensitivity Tests
- Neisseria gonorrhoeae
(drug effects, isolation & purification)
- Turkey
- Ureaplasma urealyticum
(drug effects, isolation & purification)
- Urethritis
(microbiology)
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