Antiinflammatory activity of the pectic polysaccharide from Comarum palustre.

Abstract

A pectic polysaccharide named comaruman (CP) was extracted from the aerial part of Comarum palustre with 0.7% aqueous ammonium oxalate and subsequent precipitation with ethanol. Oral administration of comaruman (5-100 mg/kg) was found to reduce a paw edema observed 24 h after injection of 2% formalin in mice. A fraction of comaruman (CP-H9) exhibited a similar antiinflammatory activity. Comaruman, CP deprived of lipid, CP purified by proteins and CP fractions obtained with acidic hydrolysis inhibit spontaneous and phorbol-12-myristate-13-acetate-activated adhesion of peritoneal leukocytes in vitro.

• Authors: S V Popov, G Yu Popova, R G Ovodova, Yu S Ovodov
• Journal: Fitoterapia (Fitoterapia) Vol. 76 Issue 3-4 Pg. 281-7 (Jun 2005) ISSN: 0367-326X [Print] Netherlands
• PMID: 15885926 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• comaruman
• Pectins
• Indomethacin

Topics

• Animals
• Anti-Inflammatory Agents (chemistry, pharmacology)
• Cell Adhesion (drug effects)
• Dose-Response Relationship, Drug
• Edema (drug therapy)
• Indomethacin (pharmacology)
• Leukocytes (drug effects, physiology)
• Male
• Mice
• Pectins (chemistry, pharmacology)
• Peritoneal Cavity (cytology)
• Plant Components, Aerial
• Rosaceae (chemistry)