Abstract | BACKGROUND: OBJECTIVE: The objective of the study was to ascertain whether diabetes significantly modifies oxidative status in patients with CP. DESIGN: CP patients with or without DM were compared with type 1 DM patients and healthy control subjects. RESULTS: Two-way factorial analyses showed that a decrease in the plasma concentrations of vitamin A, vitamin E, and carotenoids accompanied both CP and DM, and CP was also associated with lower plasma concentrations of selenium and zinc, lower catalase activity, and higher plasma concentrations of copper. The lag phase of LDL oxidation was lower in CP patients with or without DM than in the control subjects, whereas there was no significant difference between type 1 DM patients and control subjects. Multivariate analysis showed that LDL vitamin E (R2 = 0.24, P < 0.0001) and fasting plasma glucose (R2 = 0.32, P < 0.0001) concentrations were the main determinants of the lag phase of LDL oxidation. CONCLUSIONS:
Antioxidant status is altered in CP patients, particularly in those who also have DM. In these patients, a vitamin E deficiency and an elevated plasma glucose concentration were associated with significantly higher LDL oxidizability.
|
Authors | Didier Quilliot, Evelyne Walters, Jean-Paul Bonte, Jean-Charles Fruchart, Patrick Duriez, Olivier Ziegler |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 81
Issue 5
Pg. 1117-25
(May 2005)
ISSN: 0002-9165 [Print] United States |
PMID | 15883437
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antioxidants
- Blood Glucose
- Vitamin A
- Vitamin E
- Selenium
- Zinc
- Ascorbic Acid
|
Topics |
- Adult
- Antioxidants
(metabolism)
- Ascorbic Acid
(blood)
- Blood Glucose
- Body Mass Index
- Case-Control Studies
- Chronic Disease
- Diabetes Mellitus
(blood, etiology)
- Humans
- Male
- Middle Aged
- Oxidative Stress
- Pancreatitis
(blood, complications)
- Selenium
(blood)
- Vitamin A
(blood)
- Vitamin E
(blood)
- Zinc
(blood)
|