HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Relationship between serum alanine aminotransferase levels and liver histology in chronic hepatitis C-infected patients.

AbstractBACKGROUND:
The efficacy of serum alanine aminotransferase (ALT) levels in predicting the severity of hepatitis C virus (HCV) infection is unclear.
OBJECTIVE:
To compare histologic scoring of liver pathology in patients with chronic HCV infection with normal or elevated serum ALT.
METHODS:
Liver biopsies were performed in patients with HCV infection and either normal (n=40) or elevated (n=76) serum ALT levels, and scored for activity and fibrosis using the modified histological activity index.
RESULTS:
Patients with normal ALT and elevated ALT had similar demographic features. Median (range) histological activity grade was higher in patients with elevated ALT than in those with normal ALT (6 [1-15] vs. 5 [0-11], respectively; p=0.001), as was the fibrosis stage (2 [0-6] vs. 1[0-6]; p=0.02). Two patients with normal ALT and 4 with elevated ALT had liver cirrhosis.
CONCLUSIONS:
Among patients with chronic HCV infection, liver lesions are milder in those with normal serum ALT levels than those with abnormal ALT levels. However, some patients with normal ALT too may have advanced liver disease.
AuthorsTaraneh Dor-Mohammadi, Nasser Ebrahimi Daryani, Mohammad Bashashati, Ali-Asad Hashtrudi, Babak Haghpanah, Ali-Reza Sayyah, Madjid Shakiba
JournalIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology (Indian J Gastroenterol) 2005 Mar-Apr Vol. 24 Issue 2 Pg. 49-51 ISSN: 0254-8860 [Print] India
PMID15879648 (Publication Type: Journal Article)
Chemical References
  • Alanine Transaminase
Topics
  • Adolescent
  • Adult
  • Aged
  • Alanine Transaminase (blood)
  • Female
  • Hepatitis C, Chronic (enzymology, pathology)
  • Humans
  • Liver (pathology)
  • Male
  • Middle Aged
  • Retrospective Studies

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: