Evaluation of commercial assay detecting specific immunoglobulin g in oral fluid for determining measles immunity in vaccinees.

Abstract

A commercial assay for detection of measles immunoglobulin G (IgG) in oral fluid was evaluated in a highly vaccinated cohort using serum IgG as gold standard. In contrast to previous studies from cohorts protected by natural immunity, antibody prevalence was significantly underestimated (-7.4%; confidence interval: -1.5 to -13.2%; P = 0.01) due to a reduced sensitivity when antibody levels were low.

• Authors: Jacques R Kremer, Claude P Muller
• Journal: Clinical and diagnostic laboratory immunology (Clin Diagn Lab Immunol) Vol. 12 Issue 5 Pg. 668-70 (May 2005) ISSN: 1071-412X [Print] United States
• PMID: 15879031 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Viral
• Immunoglobulin G
• Measles Vaccine
• Reagent Kits, Diagnostic

Topics

• Antibodies, Viral (analysis)
• Antibody Formation (drug effects)
• Cohort Studies
• Humans
• Immunoglobulin G (analysis)
• Measles (therapy)
• Measles Vaccine (pharmacology)
• Reagent Kits, Diagnostic (standards)
• Saliva (immunology)
• Sensitivity and Specificity