Cyproterone acetate and ethinylestradiol-induced pill oesophagitis: a case report.

Abstract

Although there are many cases of oesophagitis related to pill in medical literature, there are only a few reports concerning oesophagitis related to oral contraceptives, and none about cyproterone acetate and ethinylestradiol combination (Diane-35). In this report, we describe a female patient who suffered from odynophagia and retrosternal pain after taking Diane-35 for hirsutism. The endoscopic examination revealed two well-demarcated circumferential ulcers of 1 cm diameter surrounded by relatively normal mucosa in mid-oesophagus. The patient had gone to bed immediately after taking the pill. Oral intake was stopped, and intravenous fluids and omeprazole were administered as part of treatment. The patient benefited from this approach very quickly and was discharged from hospital in 5 days. The oesophagus was completely normal in control endoscopy after 2 months. Diane-35 should be added to the list of drugs causing pill oesophagitis, and physicians should inform the patients that the pills should be taken with enough water and they should not lie down right after ingesting the pills.

• Authors: M T Gulsen, N M Buyukberber, M Karaca, A Kadayifci
• Journal: International journal of clinical practice. Supplement (Int J Clin Pract Suppl) Issue 147 Pg. 79-81 (Apr 2005) ISSN: 1368-504X [Print] England
• PMID: 15875632 (Publication Type: Case Reports, Journal Article)

Chemical References

• Androgen Antagonists
• Drug Combinations
• Tablets
• Ethinyl Estradiol
• Cyproterone Acetate
• Cyproterone acetate, ethinyl estradiol drug combination

Topics

• Adult
• Androgen Antagonists (adverse effects)
• Cyproterone Acetate (adverse effects)
• Drug Combinations
• Esophagitis (chemically induced)
• Esophagoscopy
• Ethinyl Estradiol (adverse effects)
• Female
• Hirsutism (drug therapy)
• Humans
• Tablets
• Ulcer (chemically induced)