Abstract | PURPOSE: METHODS: In a randomized, double-blind, placebo-controlled trial, 90 patients, 40 males and 50 females, scheduled for elective plastic surgery received either lidocaine 20 mg plus metoclopramide 10 mg iv, lidocaine 20 mg iv, or placebo (saline); ( n = 30 in each), with venous occlusion for one minute, followed by administration of propofol 0.5 mg.kg(-1) into a dorsal hand vein. Pain was assessed on a four-point scale (0 = none, 1 = mild, 2 = moderate, 3 = severe) during propofol injection. RESULTS: 25 patients (83%) complained of pain in the placebo group, compared with 12 (40%) in the lidocaine group (P < 0.05) and three (10%) in the combination group (P < 0.05). Pain score (median) was less in the lidocaine (0) and combination (0) groups than in the placebo group (2); (P < 0.05). The difference in the incidence of pain between the combination and lidocaine groups was significant (P < 0.05). CONCLUSION:
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Authors | Yoshitaka Fujii, Masahiro Nakayama |
Journal | Canadian journal of anaesthesia = Journal canadien d'anesthesie
(Can J Anaesth)
Vol. 52
Issue 5
Pg. 474-7
(May 2005)
ISSN: 0832-610X [Print] United States |
PMID | 15872124
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Retracted Publication)
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Chemical References |
- Anesthetics, Intravenous
- Lidocaine
- Metoclopramide
- Propofol
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Topics |
- Adult
- Anesthetics, Intravenous
(administration & dosage)
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Humans
- Injections, Intravenous
(adverse effects)
- Lidocaine
(administration & dosage)
- Male
- Metoclopramide
(administration & dosage)
- Middle Aged
- Pain
(prevention & control)
- Propofol
(administration & dosage)
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