| Abstract | BACKGROUND: Hormone sensitive lipase (HSL) plays a central role in free fatty acid homeostasis in adipose tissue and in pancreatic beta-cells, where it contributes to the control of insulin secretion by generating long-chain fatty acids. AIM: We examined the frequency and association of the functional HSL promoter variant, -60C>G, in a German cohort of morbidly obese women (N=239) and men (N=55) and compared the frequency to a cohort of 199 blood donors, recruited from the same region. RESULTS: The rare allele frequency of -60C>G, in the obese individuals was significantly lower 0.031 (95% CI 0.02, 0.04), than that in the blood donors 0.061 (95% CI 0.04, 0.08) p=0.05. The association of the HSL -60C>G with lipid and glucose parameters was examined in the obese women (there were too few men for comparative analysis). In the obese women, those heterozygous for the -60G had significantly higher glucose levels compared to CC women, 142.71 (+/-16.23) mg/dl vs. 110.34 (+/-1.79) mg/dl, respectively (p=0.0001). There was no statistically significant difference in other parameters. CONCLUSION: This study confirms a role for HSL in glucose homeostasis and the reduced frequency of the low expressing -60G promoter variant in obese individuals, together with existing published data, suggests that this allele might be protective against obesity. |
| Authors | Philippa J Talmud, Jutta Palmen, Anna M Wolf, Ulrike Beisiegel
(Affiliation: Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Department of Medicine, The Rayne Institute, Royal Free and University College Medical School, London WC1E 6JF, UK. p.talmud at ucl.ac.uk)
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| Journal | Nutrition, metabolism, and cardiovascular diseases : NMCD
(Nutr Metab Cardiovasc Dis)
Vol. 15
Issue 1
Pg. 31-5
(Feb 2005)
ISSN: 0939-4753 Germany |
| PMID | 15871848
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Blood Glucose
- Leptin
- Insulin
- Lipase
|
| Topics |
- Adult
- Blood Glucose
(metabolism)
- Cohort Studies
- Female
- Gene Frequency
- Genetic Variation
- Humans
- Insulin
(metabolism)
- Leptin
(blood)
- Lipase
(blood, genetics)
- Lipid Metabolism
- Male
- Middle Aged
- Obesity, Morbid
(blood, genetics, metabolism)
- Promoter Regions, Genetic
(genetics)
|
