Lyprinol (stabilised lipid extract of New Zealand green-lipped mussel): a potential preventative treatment modality for inflammatory bowel disease.

Abstract

BACKGROUND:

Lyprinol (Pharmalink International), the stabilised lipid extract of the New Zealand green-lipped mussel, is currently used to relieve symptoms of arthritis. We investigated the effect of pretreatment with Lyprinol (LYP) on experimentally induced inflammatory bowel disease (IBD) in mice.

METHODS:

Male C57BL/6 mice (aged 6 weeks) were gavaged daily for 13 days with (150 microl) olive oil (OO; n = 7), fish oil (FO; n = 8), or LYP (n = 8). Mice consumed 2% dextran sulfate sodium (DSS) for 6 days, starting on day 7. Body weight and disease activity index (DAI) scores were recorded daily. Colonic damage was determined by histopathology. Colonic inflammation was quantified by myeloperoxidase (MPO) activity.

RESULTS:

LYP treatment significantly (P < 0.05) reduced body weight loss, DAI scores, crypt area losses, and cecum and colon weights, compared with FO treatment. MPO activity was not significantly affected by any treatment.

CONCLUSIONS:

These findings provide preliminary evidence that Lyprinol may be potentially useful in ameliorating symptoms of IBD. The benefit, however, is unlikely to be due to the omega-3 fatty acid content. Dose-response evaluation of Lyprinol in experimental IBD is warranted.

• Authors: Danik Tenikoff, Karen J Murphy, Maria Le, Peter R Howe, Gordon S Howarth
• Journal: Journal of gastroenterology (J Gastroenterol) Vol. 40 Issue 4 Pg. 361-5 (Apr 2005) ISSN: 0944-1174 [Print] Japan
• PMID: 15870972 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Fish Oils
• Lipids
• Olive Oil
• Plant Oils
• Plasma Substitutes
• lyprinol
• Dextran Sulfate
• Peroxidase

Topics

• Administration, Oral
• Animals
• Body Weight (drug effects)
• Colitis, Ulcerative (chemically induced, pathology, prevention & control)
• Colon (drug effects, enzymology, pathology)
• Dextran Sulfate (toxicity)
• Disease Models, Animal
• Disease Progression
• Drug Therapy, Combination
• Fish Oils (administration & dosage, therapeutic use)
• Follow-Up Studies
• Lipids (administration & dosage, therapeutic use)
• Male
• Mice
• Mice, Inbred C57BL
• Olive Oil
• Organ Size (drug effects)
• Peroxidase (metabolism)
• Plant Oils (administration & dosage, therapeutic use)
• Plasma Substitutes (toxicity)
• Treatment Outcome