Abstract | PURPOSE: EXPERIMENTAL DESIGN:
mGluR4 expression was investigated in 21 normal and 312 malignant tissues from various organs using immunohistochemistry. In addition, 241 cases of colorectal carcinomas were examined and correlations between mGluR4 expression and various clinicopathologic parameters were then statistically analyzed. RESULTS: Expression of mGluR4 was identified in the normal epithelia of the upper respiratory tract, gastrointestinal tracts, breast, uterine cervix, urinary bladder, and skin, whereas it was not detected in the thyroid, lung alveoli, liver, testis, or prostate. In the corresponding malignant tissues, mGluR4 expression was frequently identified in colorectal carcinoma (68%), followed by malignant melanoma, laryngeal carcinoma, and breast carcinomas. Expression of mGluR4 was detected in 131 (54%) of 241 colorectal carcinomas and 12 (5%) cases among them showed overexpression in their cytoplasms. Loss of mGluR4 expression was negatively associated with tumor differentiation (P = 0.028), whereas overexpression of mGluR4 was positively associated with recurrence (P = 0.034) and poor disease-free survival (P = 0.017) in multivariate analyses. CONCLUSIONS:
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Authors | Hee Jin Chang, Byong Chul Yoo, Seok-Byung Lim, Seung-Yong Jeong, Woo Ho Kim, Jae-Gahb Park |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 11
Issue 9
Pg. 3288-95
(May 01 2005)
ISSN: 1078-0432 [Print] United States |
PMID | 15867225
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aminobutyrates
- Receptors, Metabotropic Glutamate
- 2-amino-4-phosphonobutyric acid
- metabotropic glutamate receptor 4
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Topics |
- Aminobutyrates
(pharmacology)
- Blotting, Western
- Cell Line, Tumor
- Cell Movement
(drug effects)
- Cell Proliferation
(drug effects)
- Colorectal Neoplasms
(metabolism, pathology)
- Female
- Humans
- Immunohistochemistry
- Male
- Prognosis
- Receptors, Metabotropic Glutamate
(agonists, antagonists & inhibitors, biosynthesis)
- Survival Analysis
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