HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Selective estrogen receptor modulator and selective progesterone receptor modulator: therapeutic efficacy in the treatment of uterine leiomyoma.

Abstract
Recent advances in endocrinology open a door for clinical application of selective estrogen receptor modulator (SERM) and selective progesterone receptor modulator (SPRM) in the treatment of uterine leiomyoma. With regard to SERM, treatment with raloxifene is shown to reduce leiomyoma size in postmenopausal women. Although raloxifene causes shrinkage of leiomyomas in combination with gonadotropin-releasing hormone agonist in premenopausal women, the effects of monotherapy with raloxifene on leiomyoma growth in premenopausal women remain controversial. By contrast, tamoxifen may not be suitable for long-term treatment of leiomyomas due to an agonistic action on the endometrium. Treatment with progesterone antagonist (RU486) or SPRM (J867) has been demonstrated to inhibit leiomyoma growth and improve clinical symptoms in premenopausal women. No serious adverse effects associated with SERM or SPRM have been reported. In light of therapeutic efficacy and few adverse effects, SERM and SPRM may hold promise as novel treatment modalities for leiomyoma. Further studies are warranted to determine the optimal strategy for the treatment of leiomyoma with SERM and SPRM.
AuthorsN Ohara
JournalClinical and experimental obstetrics & gynecology (Clin Exp Obstet Gynecol) Vol. 32 Issue 1 Pg. 9-11 ( 2005) ISSN: 0390-6663 [Print] Italy
PMID15864926 (Publication Type: Editorial, Review)
Chemical References
  • Fertility Agents, Female
  • Hormone Antagonists
  • Receptors, Progesterone
  • Selective Estrogen Receptor Modulators
  • Gonadotropin-Releasing Hormone
Topics
  • Female
  • Fertility Agents, Female (therapeutic use)
  • Gonadotropin-Releasing Hormone (agonists)
  • Hormone Antagonists (therapeutic use)
  • Humans
  • Leiomyoma (drug therapy)
  • Receptors, Progesterone (agonists, antagonists & inhibitors)
  • Selective Estrogen Receptor Modulators (therapeutic use)
  • Uterine Neoplasms (drug therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: