May glutathione S-transferase M1 positive genotype afford protection against primary open-angle glaucoma?

Abstract

PURPOSE:

To find out whether the polymorphism at GSTM1, GSTT1 and GSTP1 loci is associated with increased susceptibility to glaucoma.

METHODS:

We genotyped 153 primary open angle patients and 159 healthy controls. Genomic DNA from peripheral blood was examined using polymerase chain reaction and defined for the genetic polymorphisms of glutathione S-transferase.

RESULTS:

The frequency of the GSTM1 null genotype individuals among the glaucoma patients was significanlty higher than in controls (54.9 vs 40.9%) with odds ratio of 1.64 (95% CI: 1.10-2.59). The frequency of the GSTT1 and GSTP1 in both groups were not statistically different.

CONCLUSION:

The present study suggests that the GSTM1 null genotype may be a genetic risk factor for development of primary open angle glaucoma. Further associations studies in other polymorphic genes for xenobiotic-metabolizing enzymes are needed to elucidate the environmental-genetic interaction in the underlying cause of primary open angle glaucoma.

• Authors: Ozlem Yildirim, Nurcan Aras Ateş, Lülüfer Tamer, Ozay Oz, Ayça Yilmaz, Uĝur Atik, Handan Camdeviren
• Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (Graefes Arch Clin Exp Ophthalmol) Vol. 243 Issue 4 Pg. 327-33 (Apr 2005) ISSN: 0721-832X [Print] Germany
• PMID: 15864623 (Publication Type: Journal Article)

Chemical References

• DNA Primers
• Isoenzymes
• glutathione S-transferase T1
• GSTP1 protein, human
• Glutathione S-Transferase pi
• Glutathione Transferase
• glutathione S-transferase M1

Topics

• Adult
• Aged
• DNA Primers (chemistry)
• Female
• Genotype
• Glaucoma, Open-Angle (enzymology, genetics)
• Glutathione S-Transferase pi
• Glutathione Transferase (genetics)
• Humans
• Intraocular Pressure
• Isoenzymes (genetics)
• Male
• Middle Aged
• Polymerase Chain Reaction
• Polymorphism, Genetic
• Risk Factors