Abstract |
Chuling, sclerotia of Polyporus umbellatus FRIES, has long been used for urological disorders in traditional medicine. In this study, we demonstrated that Chuling in vitro protects red blood cells from 2,2-azo-bis(2-amidinopropane)dihydrochloride ( AAPH)-induced hemolysis. The inhibitory effect was dose-dependent at concentrations of 50 to 1000 microg/ml. Moreover, tests were carried out to identify the main ingredient of Chuling with scavenging effect on free radicals. Triterpene carboxylic acids isolated from the methanol extract of Chuling, namely, polyporusterone A and polyporusterone B, were found to have inhibitory activities against AAPH-induced lysis of red blood cells. The anti-hemolytic effect was significantly stronger in polyporusterone B compared with polyporusterone A. Furthermore, the ingestion of 150 mg of Chuling was associated with a significant increase in free-radical scavenging effect of plasma in rats.
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Authors | Nobuyasu Sekiya, Hiroaki Hikiami, Yoichiro Nakai, Iwao Sakakibara, Kazuya Nozaki, Kazufumi Kouta, Yutaka Shimada, Katsutoshi Terasawa |
Journal | Biological & pharmaceutical bulletin
(Biol Pharm Bull)
Vol. 28
Issue 5
Pg. 817-21
(May 2005)
ISSN: 0918-6158 [Print] Japan |
PMID | 15863885
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Free Radical Scavengers
- Free Radicals
- Triterpenes
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Topics |
- Dose-Response Relationship, Drug
- Erythrocytes
(drug effects, metabolism)
- Free Radical Scavengers
(isolation & purification, pharmacology)
- Free Radicals
(antagonists & inhibitors, pharmacology)
- Hemolysis
(drug effects, physiology)
- Humans
- Male
- Polyporales
(isolation & purification)
- Triterpenes
(isolation & purification, pharmacology)
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