Mechanism of proliferation arrest of embryonic cells of Xenopus by diterpene compounds.

Abstract

Three diterpene compounds isolated from the anti-cancer herbal medicine kansui, namely, kansuinin B, 20-OD-ingenol Z, and 20-OD-ingenol E, specifically inhibited the proliferation of isolated embryonic cells from Xenopus embryos. We conducted a cytologic study to determine the mechanism underlying the arrest of the cellular proliferation by these compounds. While kansuinin B and 20-OD-ingenol Z treatment decreased the cell numbers in the S phase and the M phase substages of the cell cycle, 20-OD-ingenol E inhibited mitosis.

• Authors: Tomoharu Okouchi, Tetsuya Abe, Shusuke Araki, Shinsuke Arai, Takashi Iida, Li-Yan Wang, Susumu Kitanaka, Shohei Miyata
• Journal: Bioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 13 Issue 11 Pg. 3847-51 (Jun 01 2005) ISSN: 0968-0896 [Print] England
• PMID: 15863009 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Diterpenes

Topics

• Animals
• Cell Division (drug effects)
• Cells, Cultured
• Diterpenes (pharmacology)
• Female
• Male
• S Phase (drug effects)
• Xenopus laevis (embryology)