| Abstract | AIM: To investigate CTGF's role in bleomycin-induced pulmonary fibrosis. METHODS: Kunming mice were intratracheally administered with bleomycin to establish pulmonary fibrosis model. The expression of CTGF was studied by immunohistochemical method and RT-PCR. The degree of fibrosis was evaluated by pulmonary hydroxyproline assay. RESULTS: CTGF protein and mRNA were not expressed in normal mice. However, they were detected in pulmonary fibrotic mice from day 7 after bleomycin treatment, and increased as fibrosis developed (P <0.01). CTGF protein's expression was correlated with hydroxyproline content in lung tissue (r=0.92, P <0.01). CONCLUSION: CTGF plays a role in pulmonary fibrosis. Detection of CTGF may be an early and sensitive marker for evaluating the occurrence and development of pulmonary fibrosis. |
| Authors | Lei Zhang, Hui-ping Lu, Guo-xiang Lai
(Affiliation: Department of Respiratory Disease, Fuzhou General Hospital of Nanjing Military Command, Fuzhou 350025, China. sunray168 at 126.com)
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| Journal | Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
(Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi)
Vol. 21
Issue 3
Pg. 290-2
(May 2005)
ISSN: 1007-8738 China |
| PMID | 15862142
(Publication Type: English Abstract, Journal Article)
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