[Experiment study on the estrogen-like effect of compounds of mercury, chromium and manganese].

Abstract

OBJECTIVE:

In order to study estrogen-like effect of compounds of Mercury, Chromium and Manganese.

METHODS:

Mercury Chloride, Manganese Sulfate, Chromium Chloride and Chromium trioxide were selected to perform proliferation assay of MCF-7 human breast cancer cells and binding assay of estrogen receptor for rat uterine.

RESULTS:

Mercury Chloride could stimulate the proliferation of MCF-7 cell, the maximal increase of MCF-7 cells was measured by Mercury Chloride at 10(-7) mol/L. The effect was blocked completely by a pure antigestrogen ICI182, 780; but Mercury Chloride could not bind to ER by competing with E2. Chromium Chloride, Chromium Trioxide and Manganese Sulfate were not able to stimulate the proliferation of MCF-7 cell and bind to ER through competing against 3H-E2 in vitro.

CONCLUSION:

Mercury Chloride exhibited the estrogenicity through binding and activating ER; Chromium Chloride, Chromium trioxide and Manganese Sulfate did not show any estrogenicity.

• Authors: Ya-Dong Wang, Xiao-Yu Chen, Yi-Ming Wu, Dong Xu
• Journal: Wei sheng yan jiu = Journal of hygiene research (Wei Sheng Yan Jiu) Vol. 34 Issue 1 Pg. 49-51 (Jan 2005) ISSN: 1000-8020 [Print] China
• PMID: 15862022 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Chlorides
• Chromium Compounds
• Endocrine Disruptors
• Environmental Pollutants
• Manganese Compounds
• Receptors, Estrogen
• Sulfates
• Mercuric Chloride
• chromium trioxide
• chromous chloride
• manganese sulfate

Topics

• Animals
• Binding, Competitive
• Breast Neoplasms (metabolism, pathology)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Chlorides (pharmacology)
• Chromium Compounds (pharmacology)
• Endocrine Disruptors (pharmacology)
• Environmental Pollutants (pharmacology)
• Female
• Humans
• Manganese Compounds (pharmacology)
• Mercuric Chloride (pharmacology)
• Rats
• Rats, Sprague-Dawley
• Receptors, Estrogen (metabolism)
• Sulfates (pharmacology)