Effects of air pollutants on childhood asthma.

Abstract

Epidemiologic studies have suggested the association between environmental exposure to volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs) and the increased risk of incurring asthma. Yet there is little data regarding the relationship between personal exposure to air pollution and the incidence of asthma in children. This study was designed to evaluate the effect of exposure to air pollution on children with asthma by using exposure biomarkers. We assessed the exposure level to VOCs by measuring urinary concentrations of hippuric acid and muconic acid, and PAHs by 1-OH pyrene and 2-naphthol in 30 children with asthma and 30 children without asthma (control). The mean level of hippuric acid was 0.158 +/- 0.169 micromol/mol creatinine in the asthma group and 0.148 +/- 0.249 micromol/mol creatinine in the control group, with no statistical significance noted (p=0.30). The mean concentration of muconic acid was higher in the asthma group than in the control group (7.630 +/- 8.915 micromol/mol creatinine vs. 3.390 +/- 4.526 micromol/mol creatinine p=0.01). The mean level of urinary 1-OHP was higher in the asthma group (0.430 +/- 0.343 micromol/mol creatinine) than the control group (0.239 +/- 0.175 micromol/mol creatinine), which was statistically significant (p=0.03). There was no difference in the mean concentration of 2-NAP between the two groups (9.864 +/- 10.037 micromol/mol in the asthma group vs. 9.157 +/- 9.640 micromol/mol in the control group, p=0.96). In conclusion, this study suggests that VOCs and PAHs have some role in asthma.

• Authors: Jeong-Hee Kim, Ja-Kyoung Kim, Byong-Kwan Son, Ji-Eun Oh, Dae-Hyun Lim, Kwan-Hee Lee, Youn-Chol Hong, Sung-Il Cho
• Journal: Yonsei medical journal (Yonsei Med J) Vol. 46 Issue 2 Pg. 239-44 (Apr 30 2005) ISSN: 0513-5796 [Print] Korea (South)
• PMID: 15861497 (Publication Type: Journal Article)

Chemical References

• Air Pollutants
• Hippurates
• Naphthols
• Organic Chemicals
• Polycyclic Aromatic Hydrocarbons
• Pyrenes
• muconic acid
• Creatinine
• 1-hydroxypyrene
• 2-naphthol
• hippuric acid
• Sorbic Acid

Topics

• Air Pollutants (pharmacology)
• Asthma (physiopathology, urine)
• Case-Control Studies
• Child, Preschool
• Creatinine (urine)
• Female
• Hippurates (urine)
• Humans
• Male
• Naphthols (urine)
• Organic Chemicals (chemistry, pharmacology)
• Polycyclic Aromatic Hydrocarbons (pharmacology)
• Pyrenes (metabolism)
• Sorbic Acid (analogs & derivatives, metabolism)
• Volatilization