Analysis of breast reduction complications derived from the BRAVO study.

Abstract

BACKGROUND:

Analysis of complication data derived from the Breast Reduction Assessment: Value and Outcomes (BRAVO) study, a 9-month prospective, multicenter trial, is presented.

METHODS:

Data derived from 179 patients were analyzed, including bivariate associations between complications and single predictor variables (Fisher's exact test or chi-square testing) or continuous variables (two-sample t test) and, finally, logistic regression.

RESULTS:

The overall complication rate was 43 percent (77 patients). Simple, bivariate analysis linked preoperative breast volume, shoulder strap grooving, and a vertical incision with an increased incidence of complications (p < 0.05, 0.02, and 0.02, respectively). Delayed wound healing, the most common complication, correlated directly with average preoperative breast volume (p < 0.045), average resection weight/breast (p < 0.027), and smoking (p < 0.029) and inversely with age (p < 0.011). Vertical incision techniques were associated with an increased complication frequency (p < 0.05) without a link to specific complications. Logistic regression analysis associated resection weight as the sole variable for increased risk of complications (p = 0.05) and with absolute number of complications [mean resection weight of 791 g for patients without complications versus 847, 882, and 1752 g for patients with one, two, and three complications, respectively (p = 0.0022)]. Each 10-fold increase in resection weight increased the risk of complication 4.8 times and increased the risk of delayed healing 11.6 times.

CONCLUSIONS:

Complication data revealed several significant features: (1) resection weight correlated with increased risk and absolute number of complications; (2) delayed healing correlated directly with resection weight and inversely with increasing age, anesthesia times, and preoperative Short Form-36 bodily pain score; (3) a vertical incision may be associated with increased incidence of complications but requires further analysis; and most importantly, (4) the presence of complications had no negative effect on improvement in Short Form-36 and Multidimensional Body-Self Relations Questionnaire scores.

• Authors: Bruce L Cunningham, Andrew J L Gear, Carolyn L Kerrigan, E Dale Collins
• Journal: Plastic and reconstructive surgery (Plast Reconstr Surg) Vol. 115 Issue 6 Pg. 1597-604 (May 2005) ISSN: 1529-4242 [Electronic] United States
• PMID: 15861063 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Body Mass Index
• Chi-Square Distribution
• Female
• Health Status Indicators
• Humans
• Logistic Models
• Mammaplasty (adverse effects, methods)
• Multicenter Studies as Topic
• Prospective Studies
• Retrospective Studies
• Wound Healing