Safety study of a beef-based chewable tablet formulation of ivermectin and pyrantel pamoate in growing dogs, pups, and breeding adult dogs.

Abstract

To determine the safety of a new combination of ivermectin and pyrantel (as pamoate salt) in a novel beef-based chewable tablet formulation, 3 tolerance trials were conducted and included growing dogs, pups, and breeding adult dogs. Growing dogs, given the combination orally for 5 consecutive days at recommended dosages (5 mg of pyrantel/kg of body weight, 6 micrograms of ivermectin/kg) or at twice the pyrantel dosage in combination with the recommended dosage of ivermectin, had no adverse effects. The combination also was administered to 6-week-old pups at 1, 3, and 5 times the recommended dose on 3 successive days for 3 times in 1 month. Compared with age-matched controls, treatment had no effect on clinical status, growth rate, or gross or histologic features. Breeding male and female dogs given the combination at 3 times the recommended dose for extended periods had no adverse effects, and prevalence of abnormalities in the offspring was not greater than that in nonmedicated controls.

• Authors: J N Clark, J D Pulliam, C P Daurio
• Journal: American journal of veterinary research (Am J Vet Res) Vol. 53 Issue 4 Pg. 608-12 (Apr 1992) ISSN: 0002-9645 [Print] United States
• PMID: 1586037 (Publication Type: Journal Article)

Chemical References

• Drug Combinations
• Tablets
• Ivermectin
• Pyrantel Pamoate

Topics

• Abnormalities, Drug-Induced (veterinary)
• Administration, Oral
• Animals
• Dirofilariasis (prevention & control, veterinary)
• Dog Diseases (prevention & control)
• Dogs
• Drug Combinations
• Drug Tolerance
• Female
• Fertility (drug effects)
• Fertilization (drug effects)
• Ivermectin (administration & dosage, adverse effects, therapeutic use)
• Litter Size (drug effects)
• Male
• Pyrantel Pamoate (administration & dosage, adverse effects, therapeutic use)
• Random Allocation
• Reproduction (drug effects)
• Tablets