Dihydropyrimidinase-related protein 2 (DRP-2) gene and association to deficit and nondeficit schizophrenia.

Abstract

A previous study has shown an association between the *2236T > C allele polymorphism of the dihydropyrimidinase-related protein 2 (DRP-2) gene and schizophrenia in a Japanese sample [Nakata et al. (2003); Biological Psychiatry 53:571-576]. DRP-2 is an important molecule in guiding neuronal development and its gene is located in 8p21, a chromosomal region that was previously shown to have significant linkage to schizophrenia and to several deficit symptoms of schizophrenia. We compared the frequency of the DRP-2 *2236T > C polymorphism between subjects with (n = 117) and without (n = 72) schizophrenia, and then further evaluated whether the association was specific for the deficit (n = 24) and nondeficit (n = 93) forms of schizophrenia. In both Caucasians and African-Americans, the C allele occurred more frequently in schizophrenia cases than controls, with this difference achieving statistical significance in Caucasians (C allele frequency: 42.0% in cases vs. 25.0% in controls, P = 0.014) but not African Americans (52.6% in cases vs. 50.0% in controls, P = 0.93). In Caucasians, the frequency of the C allele was significantly higher in both the deficit (allele frequency 53.3%, P = 0.009) and nondeficit (39.2%, P =0.050) forms of schizophrenia compared to controls (allele frequency 25.0%). We conclude that the DRP-2 *2236 C allele may mark another polymorphism in DRP-2, or in a nearby gene, that may influence susceptibility to schizophrenia.

• Authors: L Elliot Hong, Ikwunga Wonodi, Matthew T Avila, Robert W Buchanan, Robert P McMahon, Braxton D Mitchell, O Colin Stine, William T Carpenter Jr, Gunvant K Thaker
• Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics (Am J Med Genet B Neuropsychiatr Genet) Vol. 136B Issue 1 Pg. 8-11 (Jul 05 2005) ISSN: 1552-4841 [Print] United States
• PMID: 15858820 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
• Copyright: Copyright 2005 Wiley-Liss, Inc.

Chemical References

• Intercellular Signaling Peptides and Proteins
• Nerve Tissue Proteins
• Proteins
• collapsin response mediator protein-2

Topics

• Adult
• Black or African American (genetics)
• Alleles
• Female
• Gene Frequency
• Genotype
• Humans
• Intercellular Signaling Peptides and Proteins
• Male
• Middle Aged
• Nerve Tissue Proteins
• Polymorphism, Single Nucleotide
• Proteins (genetics)
• Schizophrenia (ethnology, genetics)
• White People (genetics)