Studies of a vascular-acting photosensitizer, Pd-bacteriopheophorbide (Tookad), in normal canine prostate and spontaneous canine prostate cancer.

Abstract

BACKGROUND AND OBJECTIVES:

Photodynamic therapy (PDT) mediated with Tookad (Pd-bacteriopheophorbide, WST09) was investigated pre-clinically as part of a program to develop an alternative modality for treating prostate cancer.

STUDY DESIGN/MATERIALS AND METHODS:

Spontaneous canine prostate cancer and normal canine prostate were used as the animal models. Interstitial PDT was performed by IV infusion of the photosensitizer and irradiating the prostates with a diode laser (763 nm). The prostates were harvested 1-week post-PDT and subjected to histopathologic examinations. The effects of the drug doses and light doses were studied for one- and two-session PDT. Pharmacokinetics were studied using HPLC assay. The feasibility of using perfusing CT scans for assessing PDT lesions was also evaluated.

RESULTS:

Tookad is a vascular-acting drug and clears rapidly from the circulation. Tookad-PDT-induced lesions, in both normal and cancerous prostates, were characterized by marked hemorrhagic necrosis.

CONCLUSIONS:

Tookad-PDT is very effective in ablating prostatic tissue through its vascular effects.

• Authors: Zheng Huang, Qun Chen, David Luck, Jill Beckers, Brian C Wilson, Nadira Trncic, Susan M Larue, Dominique Blanc, Fred W Hetzel
• Journal: Lasers in surgery and medicine (Lasers Surg Med) Vol. 36 Issue 5 Pg. 390-7 (Jun 2005) ISSN: 0196-8092 [Print] United States
• PMID: 15856509 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
• Copyright: Copyright 2005 Wiley-Liss, Inc.

Chemical References

• Bacteriochlorophylls
• Photosensitizing Agents
• palladium-bacteriopheophorbide

Topics

• Animals
• Bacteriochlorophylls (administration & dosage, pharmacokinetics)
• Dogs
• Dose-Response Relationship, Drug
• Dose-Response Relationship, Radiation
• Infusions, Intravenous
• Male
• Photochemotherapy
• Photosensitizing Agents (administration & dosage, pharmacokinetics)
• Prostate (drug effects, pathology, radiation effects)
• Prostatic Neoplasms (drug therapy, pathology)