Abstract | BACKGROUND: METHODS: RESULTS: Although similar in terms of all demographic and operative variables, the two groups differed significantly in terms of vasoplegic syndrome incidence (0% in group 1[0 of 50] vs 26% in group 2 [13 of 50]; p < 0.001). In 6 patients, the vasoplegic syndrome was refractory to norepinephrine. Four of these patients survived; the other 2 had vasoplegic syndromes that were refractory to aggressive vasopressor therapy, and they ultimately died of multiorgan failure. Stroke occurred in 1 patient. The two study groups also differed significantly in terms of average intensive care unit stay (1.2 +/- 0.5 days in group 1 vs 2.1 +/- 1.2 days in group 2; p < 0.001) and average hospital stay (6.1 +/- 1.7 days in group 1 vs 8.4 +/- 2.0 days in group 2; p < 0.001). CONCLUSIONS: Our results suggest that preoperative methylene blue administration reduces the incidence and severity of vasoplegic syndrome in high-risk patients, thus ensuring adequate systemic vascular resistance in both operative and postoperative periods and shortening both intensive care unit and hospital stays.
|
Authors | Ertuğrul Ozal, Erkan Kuralay, Vedat Yildirim, Selim Kilic, Cengiz Bolcal, Nezihi Kücükarslan, Celalettin Günay, Ufuk Demirkilic, Harun Tatar |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 79
Issue 5
Pg. 1615-9
(May 2005)
ISSN: 1552-6259 [Electronic] Netherlands |
PMID | 15854942
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
|
Chemical References |
|
Topics |
- Aged
- Cardiopulmonary Bypass
(adverse effects)
- Coronary Artery Bypass
(adverse effects)
- Female
- Hemodynamics
(drug effects)
- Humans
- Infusions, Intravenous
- Male
- Methylene Blue
(administration & dosage, therapeutic use)
- Middle Aged
- Postoperative Complications
(epidemiology, prevention & control)
- Preoperative Care
- Syndrome
- Vascular Resistance
(drug effects)
|