[Clinical efficacy of a novel hemorheological drug ascovertin in patients with vascular encephalopathy].

Abstract

Patients with stages I and II of vascular encephalopathy developing on the background of atherosclerosis were treated with ascovertin during 21 days. Ascovertin is a complex of flavonoid dihydroquercetin and ascorbic acid. The study group included 21 patients aged 45-65 years and a comparison group consisted of 10 age-matched patients un treated with ascovertin. The ascovertin treatment relieved headache, reduced vertigo and fatigability, improved cognitive functions. The reliable diminishing of whole blood viscosity due to improvement of cellular rheology indices (decrease of aggregation and increase of erythrocyte deformability as well as decrease of indices of lipid peroxidation in erythrocyte membrane and blood plasma) was observed in the stydy group but not in the comparison one.

• Authors: M B Plotnikov, D M Plotnikov, V M Alifirova, O I Aliev, M Iu Maslov, A S Vasil'ev, N A Tiukavkina
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 104 Issue 12 Pg. 33-7 ( 2004) ISSN: 1997-7298 [Print] Russia (Federation)
• Vernacular Title: Klinicheskaia éffektivnost' novogo gemoreologicheskogo preparata askovertin u bol'nykh s distsirkuliatornoĭ éntsefalopatieĭ.
• PMID: 15847324 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antioxidants
• Drug Combinations
• Flavonols
• Quercetin
• taxifolin
• Ascorbic Acid

Topics

• Aged
• Antioxidants (administration & dosage)
• Ascorbic Acid (administration & dosage)
• Blood Viscosity
• Drug Combinations
• Erythrocyte Aggregation
• Erythrocyte Deformability
• Flavonols (administration & dosage)
• Headache (drug therapy, etiology)
• Hemorheology
• Humans
• Intracranial Arteriosclerosis (blood, complications, drug therapy)
• Lipid Peroxidation
• Middle Aged
• Neuropsychological Tests
• Quercetin (administration & dosage, analogs & derivatives)
• Sleep Wake Disorders (drug therapy, etiology)
• Tinnitus (drug therapy, etiology)
• Vertigo (drug therapy, etiology)