Full genome sequence of peste des petits ruminants virus, a member of the Morbillivirus genus.

Abstract

Peste des petits ruminants virus (PPRV) causes an acute febrile illness in small ruminant species, mostly sheep and goats. PPRV is a member of the Morbillivirus genus which includes measles, rinderpest (cattle plague), canine distemper, phocine distemper and the morbilliviruses found in whales, porpoises and dolphins. Full length genome sequences for these morbilliviruses are available and reverse genetic rescue systems have been developed for the viruses of terrestrial mammals, with the exception of PPRV. This paper presents the first published full length genome sequence for PPRV. The genome was found to be consistent with the rule-of-six and open reading frames (ORFs) were identified that encoded the eight proteins characteristic of morbilliviruses. At the nucleotide (nt) level, the full length genome of PPRV was most similar to that of rinderpest, the other ruminant morbillivirus. However, at the protein level five of the six structural proteins and the V protein showed a greater similarity to the dolphin morbillivirus (DMV) while only the C and L proteins showed a high relationship to rinderpest.

• Authors: Dalan Bailey, Ashley Banyard, Pradyot Dash, Aykut Ozkul, Tom Barrett
• Journal: Virus research (Virus Res) Vol. 110 Issue 1-2 Pg. 119-24 (Jun 2005) ISSN: 0168-1702 [Print] Netherlands
• PMID: 15845262 (Publication Type: Journal Article)

Chemical References

• Viral Proteins

Topics

• Base Sequence
• Genome, Viral
• Molecular Sequence Data
• Open Reading Frames
• Peste-des-petits-ruminants virus (genetics)
• Rinderpest virus (genetics)
• Sequence Alignment
• Sequence Analysis, DNA
• Sequence Homology, Amino Acid
• Sequence Homology, Nucleic Acid
• Viral Proteins (genetics)