| Abstract | Dermatitis herpetiformis that is unable to be controlled using dapsone and a gluten-free diet presents a therapeutic challenge. Three cases that responded well to sulfasalazine are presented. Two cases, who were unable to tolerate dapsone, had a rapid response to sulfasalazine, without apparent side-effects. The third case with dapsone-responsive blistering dermatoses, presumed to be dermatitis herpetiformis on the basis of serology, showed an excellent clinical response to sulfasalazine, but after 6 weeks of therapy had to cease it because of side-effects. Sulfasalazine is metabolized variably to sulfapyridine, a sulphonamide known to be an effective therapy for dermatitis herpetiformis but no longer available. Sulfasalazine should be considered as a management option for dermatitis herpetiformis. |
| Authors | Elizabeth Willsteed, Michael Lee, Li Chuen Wong, Alan Cooper
(Affiliation: Department of Dermatology, Royal North Shore Hospital, St Leonards, New South Wales, Australia.)
|
| Journal | The Australasian journal of dermatology
(Australas J Dermatol)
Vol. 46
Issue 2
Pg. 101-3
(May 2005)
ISSN: 0004-8380 Australia |
| PMID | 15842404
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Sulfasalazine
|
| Topics |
- Administration, Oral
- Adult
- Aged
- Anemia, Pernicious
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage)
- Dermatitis Herpetiformis
(diagnosis, diet therapy, drug therapy)
- Diabetes Mellitus, Type 1
- Diagnosis, Differential
- Diet, Protein-Restricted
- Female
- Humans
- Male
- Middle Aged
- Sulfasalazine
(administration & dosage)
|
