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Occupational contact allergy and dermatitis from methylisothiazolinone after contact with wallcovering glue and after a chemical burn from a biocide.

Abstract
Skin exposure to biocides containing high concentrations of methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) may cause severe chemical burns and may also induce sensitization. We report two cases in which skin exposure to a newly launched biocide containing 2-methyl-4-isothiazolin-3-one (MI) and 1,2-benzisothiazolin-3-one led to sensitization to Ml, which in the second case was preceded by a chemical burn. A study was performed to investigate the pattern of reactivity to MCI and Ml in two patients who presumably had a primary sensitization to Ml and in one patient who had been sensitized to MCI/MI by being patch-tested. The patients were patch-tested with serial dilutions of MCI/MI, MCI, MI, and 2-n-octyl-4-isothiazolin-3-one. The first two patients reacted to both MCI/MI and the separate active ingredients, with a higher level of reactivity to Ml than to MCI. The third patient reacted to MCI/MI and MCI only. A biocide containing Ml caused sensitization and occupational contact dermatitis in the first two patients, through contact with wallpaper glue in one case and after a chemical burn in the other case.
AuthorsMarléne Isaksson, Birgitta Gruvberger, Magnus Bruze
JournalDermatitis : contact, atopic, occupational, drug (Dermatitis) Vol. 15 Issue 4 Pg. 201-5 (Dec 2004) ISSN: 1710-3568 [Print] United States
PMID15842065 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Adhesives
  • Allergens
  • Thiazoles
Topics
  • Adhesives (adverse effects)
  • Allergens (adverse effects)
  • Burns, Chemical
  • Construction Materials (adverse effects)
  • Dermatitis, Allergic Contact (diagnosis, etiology, pathology)
  • Dermatitis, Occupational (diagnosis, etiology, pathology)
  • Diagnosis, Differential
  • Female
  • Hand Dermatoses (chemically induced, diagnosis, pathology)
  • Humans
  • Male
  • Middle Aged
  • Patch Tests
  • Thiazoles (adverse effects)

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