Abstract |
Skin exposure to biocides containing high concentrations of methylchloroisothiazolinone/ methylisothiazolinone (MCI/MI) may cause severe chemical burns and may also induce sensitization. We report two cases in which skin exposure to a newly launched biocide containing 2-methyl-4-isothiazolin-3-one (MI) and 1,2-benzisothiazolin-3-one led to sensitization to Ml, which in the second case was preceded by a chemical burn. A study was performed to investigate the pattern of reactivity to MCI and Ml in two patients who presumably had a primary sensitization to Ml and in one patient who had been sensitized to MCI/MI by being patch-tested. The patients were patch-tested with serial dilutions of MCI/MI, MCI, MI, and 2-n-octyl-4-isothiazolin-3-one. The first two patients reacted to both MCI/MI and the separate active ingredients, with a higher level of reactivity to Ml than to MCI. The third patient reacted to MCI/MI and MCI only. A biocide containing Ml caused sensitization and occupational contact dermatitis in the first two patients, through contact with wallpaper glue in one case and after a chemical burn in the other case.
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Authors | Marléne Isaksson, Birgitta Gruvberger, Magnus Bruze |
Journal | Dermatitis : contact, atopic, occupational, drug
(Dermatitis)
Vol. 15
Issue 4
Pg. 201-5
(Dec 2004)
ISSN: 1710-3568 [Print] United States |
PMID | 15842065
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Adhesives
- Allergens
- Thiazoles
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Topics |
- Adhesives
(adverse effects)
- Allergens
(adverse effects)
- Burns, Chemical
- Construction Materials
(adverse effects)
- Dermatitis, Allergic Contact
(diagnosis, etiology, pathology)
- Dermatitis, Occupational
(diagnosis, etiology, pathology)
- Diagnosis, Differential
- Female
- Hand Dermatoses
(chemically induced, diagnosis, pathology)
- Humans
- Male
- Middle Aged
- Patch Tests
- Thiazoles
(adverse effects)
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