Tannerella forsythia-induced alveolar bone loss in mice involves leucine-rich-repeat BspA protein.

Abstract	Tannerella forsythia (formerly Bacteroides forsythus) is one of the periodontal pathogens recently implicated in the development of periodontal disease. The cell-surface-associated, as well as the secreted, leucine-rich-repeat protein (BspA) of this bacterium have been suggested to play roles in bacterial adherence, and also in inflammation, by triggering release of pro-inflammatory cytokines from monocytes and chemokines from osteoblasts, leading to inflammation and bone resorption. In this study, we sought to determine the pathogenic potential of T. forsythia and the in vivo role of the BspA protein in pathogenesis in the mouse model of infection-induced alveolar bone loss. The results showed alveolar bone loss in mice infected with the T. forsythia wild-type strain, whereas the BspA mutant was impaired. In conclusion, evidence is presented in support of T. forsythia as an important organism involved in inducing alveolar bone loss, and the BspA protein is an important virulence factor of this bacterium.
Authors	A Sharma, S Inagaki, K Honma, C Sfintescu, P J Baker, R T Evans
Journal	Journal of dental research (J Dent Res) Vol. 84 Issue 5 Pg. 462-7 (May 2005) ISSN: 0022-0345 [Print] United States
PMID	15840784 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Antibodies, Bacterial Antigens, Bacterial Bacterial Proteins BspA protein, Bacteroides Immunoglobulin A Immunoglobulin G Leucine-Rich Repeat Proteins Proteins Virulence Factors
Topics	Alveolar Bone Loss (immunology, microbiology) Animals Antibodies, Bacterial (immunology) Antigens, Bacterial (immunology, physiology) Bacterial Proteins (immunology, physiology) Bacteroides (immunology, pathogenicity) Bacteroides Infections (immunology, microbiology) Cell Proliferation Disease Models, Animal Immunization Immunoglobulin A (immunology) Immunoglobulin G (immunology) Leucine-Rich Repeat Proteins Lymphocytes (immunology) Male Mice Mice, Inbred BALB C Mice, Inbred Strains Proteins (immunology, physiology) Repetitive Sequences, Amino Acid (physiology) Specific Pathogen-Free Organisms Virulence Factors (physiology)

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