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Cytotoxicity of xanthopterin and isoxanthopterin in MCF-7 cells.

Abstract
Human mammary carcinoma MCF-7 cell line responsiveness to the pteridines xanthopterin and isoxanthopterin was studied using the MTS assay for measurement of cell viability. The pteridines were tested at concentrations ranging from 7.8 to 500 microM singly and in 11 isoxanthopterin:xanthopterin ratios. IC50s of xanthopterin and isoxanthopterin were 109+/-13 microM (mean+/-SEM of y estimate) and 103+/-9 microM, respectively. The IC50 values for pteridine mixtures were similar although 3:1 and 4:1 isoxanthopterin:xanthopterin ratios seemed slightly more cytotoxic than other mixtures. However, ANOVA revealed no statistical differences in the cytotoxicity of mixtures.
AuthorsJean L Lord, Ann de Peyster, P J E Quintana, Robert P Metzger
JournalCancer letters (Cancer Lett) Vol. 222 Issue 1 Pg. 119-24 (May 10 2005) ISSN: 0304-3835 [Print] Ireland
PMID15837549 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Drug Combinations
  • isoxanthopterin
  • Xanthopterin
Topics
  • Antineoplastic Agents (pharmacology)
  • Breast Neoplasms
  • Cell Line, Tumor
  • Cell Survival (drug effects)
  • Drug Combinations
  • Drug Synergism
  • Humans
  • Inhibitory Concentration 50
  • Xanthopterin (pharmacology, toxicity)

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