Disseminated thrombosis-induced growth plate necrosis in rat: a unique model for growth plate arrest.

Abstract

Exposure of rats to 2-butoxyethanol (BE) produces early hemolytic anemia and disseminated thrombosis. This leads to infarctions in multiple organs, including bones and cartilage. BE, administered for different durations of exposure in two separate experiments, produced metaphyseal vascular thrombosis, growth plate infarction, and partial or complete physeal growth arrest. This reproducible model may serve as a useful tool in the study of some conditions that manifest growth plate damage. The suitability of this model for investigating the pathogenesis of growth plate necrosis and as a model for potential therapy for various human growth plate disorders are discussed.

• Authors: Meir Nyska, Shay Shabat, Philip H Long, Charles Howard, Nathan Ezov, Tal Levin-Harrus, Moshe Mittelman, Meir Redlich, Saul Yedgar, Abraham Nyska
• Journal: Journal of pediatric orthopedics (J Pediatr Orthop) 2005 May-Jun Vol. 25 Issue 3 Pg. 346-50 ISSN: 0271-6798 [Print] United States
• PMID: 15832152 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Ethylene Glycols
• Solvents
• n-butoxyethanol

Topics

• Animals
• Bone Diseases, Developmental (chemically induced, physiopathology)
• Ethylene Glycols (adverse effects)
• Female
• Growth Plate (drug effects, pathology, physiopathology)
• Humans
• Male
• Models, Animal
• Necrosis (chemically induced)
• Rats
• Solvents (adverse effects)
• Thrombosis (chemically induced)