[Methadone and sleep apnea syndrome].

Abstract

BACKGROUND:

Sleep apnea syndrome occurs when, during sleep, breathing stops for 10 seconds or longer, with an index of 5 times or more an hour. It is clinically characterized by loud snoring at night, continuous or interrupted by pauses followed by loud breathing. Sleep is fitful, broken by arousals, and yields little rest. There is daytime excessive sleepiness with repeated involuntary falling asleep, often unknown by the subject.

CLINICAL DESCRIPTION:

In this article, we describe an observation of central sleep apnea syndrome in a female patient receiving an opiate replacement therapy.

METHOD:

An analysis of the before and after methadone withdrawal polysomnograhic tracing was done for this patient.

RESULTS:

This diagnosis etiology and physiopathology are critically approached. Clinicians should be careful in treating induced sleep disorders in such patients.

CONCLUSION:

Prescribing benzodiazepines during an opiate withdrawal of the methadone type is not recommended when central apnea occurs.

• Authors: Philippe Durst, Jérôme Palazzolo, Jean-Pierre Peyrelong, Michel Berger, Michel Chalabreysse, Michel Billiard, André Vialle
• Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie (Can J Psychiatry) Vol. 50 Issue 3 Pg. 153-8 (Mar 2005) ISSN: 0706-7437 [Print] United States
• Vernacular Title: Méthadone et syndrome d'apnées du sommeil.
• PMID: 15830825 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Hydroxyzine
• Paroxetine
• Trimeprazine
• Methotrimeprazine
• Clonidine
• Methadone

Topics

• Adult
• Brain (drug effects)
• Clonidine (adverse effects, therapeutic use)
• Cocaine-Related Disorders (rehabilitation)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Drug Therapy, Combination
• Female
• Heroin Dependence (rehabilitation)
• Humans
• Hydroxyzine (adverse effects, therapeutic use)
• Methadone (adverse effects, therapeutic use)
• Methotrimeprazine (adverse effects, therapeutic use)
• Opioid-Related Disorders (rehabilitation)
• Paroxetine (adverse effects, therapeutic use)
• Polysomnography (drug effects)
• Sleep Apnea, Central (chemically induced)
• Sleep Stages (drug effects)
• Substance Withdrawal Syndrome (etiology)
• Trimeprazine (adverse effects, therapeutic use)