Evaluation of hydroxypropyl-beta-cyclodextrin in the treatment of aldicarb poisoning in rats.

Abstract

Cyclodextrins are ring-shaped oligosaccharides with a hydrophilic exterior and a hydrophobic interior. The interior cavity is capable of complexing fat-soluble molecules small enough to fit inside. Sprague-Dawley rats were used to evaluate the efficacy of hydroxypropyl-beta-cyclodextrin as treatment of aldicarb poisoning in rats. Survival times in the majority of rats dosed with aldicarb and receiving intravenous cyclodextrin were longer compared with the control rats only dosed with aldicarb per os.

• Authors: R S Verster, C J Botha
• Journal: Journal of the South African Veterinary Association (J S Afr Vet Assoc) Vol. 75 Issue 4 Pg. 182-5 (Dec 2004) ISSN: 1019-9128 [Print] South Africa
• PMID: 15830603 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Excipients
• Insecticides
• beta-Cyclodextrins
• 2-Hydroxypropyl-beta-cyclodextrin
• Aldicarb

Topics

• 2-Hydroxypropyl-beta-cyclodextrin
• Administration, Oral
• Aldicarb (poisoning)
• Animals
• Dose-Response Relationship, Drug
• Excipients (therapeutic use)
• Injections, Intravenous (veterinary)
• Insecticides (poisoning)
• Male
• Poisoning (drug therapy, veterinary)
• Random Allocation
• Rats
• Rats, Sprague-Dawley
• Treatment Outcome
• beta-Cyclodextrins (therapeutic use)