[Complete resection for giant thymic carcinoma after simultaneous combination chemotherapy].

Abstract

A 19-year-old man visited our hospital complaining of dyspnea. Chest X-ray and computed tomography (CT) showed a huge mass in the right anterior mediastinum. We diagnosed this as invasive thymoma by microscopic examination of specimens obtained by echo-guided needle biopsy. The patient underwent 6 courses chemotherapy [1st course : carboplatin (CBDCA) + doxorubicin hydrochloride (DXR) + vincristine sulfate (VCR) + cyclophosphamide (CPA), 2nd, 3rd-6th course : cisplatin (CDDP) + ADM + VCR + CPA]. At achievement of partial response (the reduction rate of the tumor size : 91.4%), the tumor was completely resected. The pathological examination of the resected specimens yielded a diagnosis of large cell carcinoma. Preoperative chemotherapy with ADOC regimen may be effective in advanced thymic carcinoma.

• Authors: Tomoyuki Ueki, Y Ueshima, H Kurioka, Y Enoki, Y Hosokawa
• Journal: Kyobu geka. The Japanese journal of thoracic surgery (Kyobu Geka) Vol. 58 Issue 4 Pg. 320-3 (Apr 2005) ISSN: 0021-5252 [Print] Japan
• PMID: 15828254 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Vincristine
• Doxorubicin
• Cyclophosphamide
• Carboplatin
• Cisplatin

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Carboplatin (administration & dosage)
• Carcinoma, Large Cell (pathology)
• Cisplatin (administration & dosage)
• Combined Modality Therapy
• Cyclophosphamide (administration & dosage)
• Doxorubicin (administration & dosage)
• Drug Administration Schedule
• Humans
• Male
• Thymoma (drug therapy, surgery)
• Thymus Neoplasms (drug therapy, surgery)
• Vincristine (administration & dosage)