Abstract | BACKGROUND: HYPOTHESIS: STUDY DESIGN: Randomized controlled clinical trial; Level of evidence, 1. METHODS: Fifty-three patients (57 shoulders) were recruited, and the authors completed a prospective, randomized, double-blinded, placebo-controlled clinical trial of continuous topical glyceryl trinitrate treatment (1.25 mg/24-h glyceryl trinitrate). RESULTS: The glyceryl trinitrate group had significantly reduced shoulder pain with activity, at night, and at rest at week 24 (P = .03); reduced internal rotation impingement at week 24 (P = .02); increased range of motion in abduction and internal rotation at week 24 (P = .04); and increased force at weeks 12 and 24 with supraspinatus muscle testing (P = .001), external rotation (P = .04), internal rotation (P = .01), adduction (P = .04), and subscapularis pushoff (P = .01). Forty-six percent of patients on glyceryl trinitrate patches were asymptomatic with activities of daily living at 6 months compared with 24% of patients with tendon rehabilitation alone (P = .007, chi(2) analysis). Mean effect size for all outcome measures was 0.26. DISCUSSION:
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Authors | Justin A Paoloni, Richard C Appleyard, Janis Nelson, George A C Murrell |
Journal | The American journal of sports medicine
(Am J Sports Med)
Vol. 33
Issue 6
Pg. 806-13
(Jun 2005)
ISSN: 0363-5465 [Print] United States |
PMID | 15827365
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Placebos
- Vasodilator Agents
- Nitroglycerin
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Topics |
- Administration, Topical
- Adult
- Aged
- Chronic Disease
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Nitroglycerin
(administration & dosage, adverse effects, therapeutic use)
- Pain
(drug therapy)
- Placebos
- Shoulder
- Tendinopathy
(physiopathology, rehabilitation)
- Vasodilator Agents
(administration & dosage, adverse effects, therapeutic use)
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