Abstract | OBJECTIVE: CASE SUMMARIES: DISCUSSION: The symptoms observed in our patients were consistent with Sternbach's criteria for ST. A review of published case reports showed a short time to onset of symptoms following the introduction of linezolid, generally within 1-3 days. Also of note is the use of relatively high dosages of serotonergic drugs. Use of the Naranjo probability scale indicated a possible relationship between the use of linezolid and the occurrence of ST in both cases. CONCLUSIONS:
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Authors | Luc Bergeron, Martin Boulé, Sébastien Perreault |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 39
Issue 5
Pg. 956-61
(May 2005)
ISSN: 1060-0280 [Print] United States |
PMID | 15827071
(Publication Type: Case Reports, Journal Article, Review)
|
Chemical References |
- Acetamides
- Anti-Infective Agents
- Cyclohexanols
- Oxazolidinones
- Serotonin Agents
- Venlafaxine Hydrochloride
- Linezolid
|
Topics |
- Acetamides
(adverse effects)
- Adult
- Aged
- Anti-Infective Agents
(adverse effects)
- Child, Preschool
- Cyclohexanols
(adverse effects)
- Drug Interactions
- Female
- Humans
- Linezolid
- Male
- Middle Aged
- Oxazolidinones
(adverse effects)
- Serotonin Agents
(adverse effects)
- Serotonin Syndrome
(chemically induced, physiopathology)
- Venlafaxine Hydrochloride
|